Tissue distribution of transcription for 29 lipid metabolism-related genes in Takifugu rubripes, a marine teleost storing lipid predominantly in liver

文献类型： 外文期刊

第一作者： Xu, Houguo

作者： Xu, Houguo;Meng, Xiaoxue;Jia, Linlin;Wei, Yuliang;Sun, Bo;Liang, Mengqing;Xu, Houguo;Wei, Yuliang;Liang, Mengqing;Meng, Xiaoxue

作者机构：

关键词： Takifugu rubripes; Tissue distribution of gene expression; Lipid metabolism; Lipid storage pattern; Fish intestine function

期刊名称：FISH PHYSIOLOGY AND BIOCHEMISTRY （ 影响因子：2.794； 五年影响因子：2.876 ）

ISSN： 0920-1742

年卷期： 2020 年 46 卷 4 期

页码：

收录情况： SCI

摘要： The tissue distribution pattern of lipid is highly diverse among different fish species. Tiger puffer has a special lipid storage pattern, storing lipid predominantly in liver. In order to better understand the lipid physiology in fish storing lipid in liver, the present study preliminarily investigated the tissue distribution of transcription for 29 lipid metabolism-related genes in tiger puffer, which are involved in lipogenesis, fatty acid oxidation, biosynthesis and hydrolysis of glycerides, lipid transport, and relevant transcription regulation. Samples of eight tissues, brain, eye, heart, spleen, liver, intestine, skin, and muscle, from fifteen juvenile tiger puffer were used in the qRT-PCR analysis. The intestine and brain had high transcription of lipogenic genes, whereas the liver and muscle had low expression levels. The intestine also had the highest transcription level of most apolipoproteins and lipid metabolism-related transcription factors. The transcription of fatty acid beta-oxidation-related genes was low in the muscle. The peroxisomal fatty acid oxidation may dominate over mitochondrial beta-oxidation in the liver and intestine of tiger puffer, and the MAG pathway probably predominates over the G3P pathway in re-acylation of absorbed lipids in the intestine. The intracellular glyceridases were highly transcribed in the brain, eye, and heart. In conclusion, in tiger puffer, the intestine could be a center of lipid metabolism whereas the liver is more likely a pure storage organ for lipid. The lipid metabolism in the muscle could also be inactive, possibly due to the very low level of intramuscular lipid.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序