Systematic analyses reveal RNA editing events involved in skeletal muscle development of goat (Capra hircus)

文献类型： 外文期刊

第一作者： Yang, Liu

作者： Yang, Liu;Li, Li;Kyei, Bismark;Guo, Jiazhong;Zhan, Siyuan;Zhao, Wei;Zhong, Tao;Wang, Linjie;Zhang, Hongping;Xu, Lingyang;Song, Yumo

作者机构：

关键词： RNA editing; Skeletal muscle development; Goat

期刊名称：FUNCTIONAL & INTEGRATIVE GENOMICS （ 影响因子：3.41； 五年影响因子：3.616 ）

ISSN： 1438-793X

年卷期： 2020 年 20 卷 5 期

页码：

收录情况： SCI

摘要： RNA editing is a posttranscriptional molecular process involved with specific nucleic modification, which can enhance the diversity of gene products. Adenosine-to-inosine (A-to-I, I is read as guanosine by both splicing and translation machinery) is the main type of RNA editing in mammals, which manifested as AG (adenosine-to-guanosine) in sequence data. Here, we aimed to explore patterns of RNA editing using RNA sequencing data from skeletal muscle at four developmental stages (three fetal periods and one postnatal period) in goat. We found the occurrences of RNA editing events raised at fetal periods and declined at the postnatal period. Also, we observed distinct editing levels of AG editing across stages, and significant difference was found between postnatal period and fetal periods. AG editing patterns in newborn goats are similar to those of 45-day embryo compared with embryo at 105 days and embryo at 60 days. In this study, we found a total of 1415 significantly differential edited AG sites among four groups. Moreover, 420 sites were obviously clustered into six time-series profiles, and one profile had significant association between editing level and gene expression. Our findings provided some novel insights into understanding the molecular mechanism of muscle development in mammals.

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