Relationship between an indel mutation within the SIRT4 gene and growth traits in Chinese cattle

文献类型： 外文期刊

第一作者： Zhang, Qingfeng

作者： Zhang, Qingfeng;Jiang, Fugui;Cheng, Haijian;Wang, Yafang;Song, Enliang;Zhang, Qingfeng;Jiang, Fugui;Cheng, Haijian;Song, Enliang;Jin, Yunyun;Lan, Xianyong;Wang, Yafang

作者机构：

关键词： Cattle; SIRT4; insertion/deletion (indel); growth traits; association

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

年卷期： 2019 年 30 卷 4 期

页码：

收录情况： SCI

摘要： Growth traits are mainly determined by genetic factors. SIRT4, a class II sirtuin, predominantly acts as an ADP-ribosyltransferase and inhibits fatty acid oxidation. In this study, a total of 1005 cattle belonging to five indigenous Chinese breeds were used to evaluate the relationship between the potential insertions/deletions (indels) within the SIRT4 gene and growth traits. The results revealed that only one intronic variation was present, which showed Hardy-Weinberg equilibrium (p > 0.05) in all the populations. The relationship analyses indicated that this indel was significantly associated with growth traits (p < 0.05), implying that SIRT4 significantly affects the growth traits. Therefore, the deletion mutation within the SIRT4 gene could be considered as a molecular marker to screen for growth traits in the cattle industry.

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