Avermectin loaded carboxymethyl cellulose nanoparticles with stimuli-responsive and controlled release properties

文献类型： 外文期刊

第一作者： Zhu, Huaxin

作者： Zhu, Huaxin;Shen, Yue;Cui, Jianxia;Wang, Anqi;Li, Ningjun;Wang, Chong;Cui, Bo;Sun, Changjiao;Zhao, Xiang;Wang, Chunxin;Gao, Fei;Zhan, Shenshan;Guo, Liang;Zhang, Liang;Zeng, Zhanghua;Wang, Yan;Cui, Haixin

作者机构：

关键词： Avermectin; Esterase-responsive; Nanoparticles; Anti-photodegradation

期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：5.645； 五年影响因子：5.749 ）

ISSN： 0926-6690

年卷期： 2020 年 152 卷

页码：

收录情况： SCI

摘要： Polyethylene glycol (PEG) was introduced into carboxymethyl cellulose (CMC) to form hydrophilic chain of PEG-CMC. Avermectin (Avm) was grafted on the long chain of PEG-CMC by use of N, N-dicyclohexylcarbodiimide (DCC) as the dehydrant and 4-dimethylaminopyridine (DMAP) as the catalyst to form the amphiphilic molecule. Then the avermectin nanoparticles was prepared with esterase-responsive sustained release successfully through self-assembly. The size of nanoparticles was less than 400 nm. Avermectin loading was 8% and the degradation rate was less than 50 % under the xenon arc lamp for 72 h. Compared with avermectin technical, it showed an obvious anti-photodegradation advantage. Compared with commercially available water-dispersible granules (WDG), the avermectin nanoparticles had a smaller contact angle on the cucumber leaf surface and there was a significant difference. The toxicity test showed that the nanoparticles have a certain insecticidal effect on the larva of Hyphantria cunea and the sensitivity increased gradually over time.

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