Evolutionary Dynamics and Age-Dependent Pathogenesis of Sub-Genotype VI.2.1.1.2.2 PPMV-1 in Pigeons

文献类型： 外文期刊

第一作者： Xie, Peng

作者： Xie, Peng;Chen, Libin;Zhang, Yifan;Lin, Qiuyan;Liao, Ming;Xu, Chenggang;Xiang, Bin;Ren, Tao;Xie, Peng;Chen, Libin;Zhang, Yifan;Lin, Qiuyan;Liao, Ming;Xu, Chenggang;Xiang, Bin;Ren, Tao;Xie, Peng;Chen, Libin;Zhang, Yifan;Lin, Qiuyan;Liao, Ming;Xu, Chenggang;Xiang, Bin;Ren, Tao;Xie, Peng;Chen, Libin;Zhang, Yifan;Lin, Qiuyan;Liao, Ming;Xu, Chenggang;Xiang, Bin;Ren, Tao;Ding, Chan

作者机构：

关键词： PPMV-1; sub-genotype VI.2.1.1.2.2; phylogenetic tree; age; pigeon; pathogenesis; transmission

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN：

年卷期： 2020 年 12 卷 4 期

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收录情况： SCI

摘要： Pigeon paramyxovirus type 1 (PPMV-1) infection causes high morbidity in pigeons, resulting in a significant burden to the poultry industry. In this study, we isolated three PPMV-1 strains from diseased pigeons collected in Guangdong Province, South China, from June 2017 to April 2019. Genetic analysis revealed that these three PPMV-1 strains and most of the PPMV-1 strains isolated from China after 2011 were clustered into sub-genotype VI.2.1.1.2.2. Our Bayesian analysis revealed that the VI.2.1.1.2.2 viruses might have originated in Europe. Phylogeographic analyses revealed that East and South China might have played a key role in seeding the VI.2.1.1.2.2 PPMV-1 epidemic in China. To characterize the effect of age at infection on the outcome of PPMV-1 infection in pigeons, we investigated the pathogenesis and transmission of the pigeon/Guangdong/GZ08/2017 (GZ08) virus in 3-, 6-, and 12-week-old pigeons. Two of six 12-week-old pigeons inoculated with GZ08 survived, and all of the 3- and 6-week-pigeons inoculated with GZ08 died. Moreover, the GZ08 virus could be transmitted to 3-, 6-, and 12-week-old naive contact pigeons. The lethality of the GZ08 virus through contact with 3-, 6-, and 12-week-old pigeons was 100%, 66.7%, and 0%, respectively, suggesting that the transmissibility of the GZ08 virus was stronger in young pigeons. These findings demonstrated that East and South China was the epicenter for dissemination of VI.2.1.1.2.2 PPMV-1, and age at infection has an impact on the outcome of PPMV-1 infection in pigeons.

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