Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

文献类型： 外文期刊

第一作者： Li, Xin

作者： Li, Xin;Yang, Ji;Xie, Xing-Long;Xu, Ya-Xi;Lv, Feng-Hua;Deng, Juan;Xu, Song-Song;Salehian-Dehkordi, Hosein;Li, Meng-Hua;Li, Xin;Xie, Xing-Long;Xu, Song-Song;Salehian-Dehkordi, Hosein;Yang, Ji;Xu, Ya-Xi;Lv, Feng-Hua;Li, Meng-Hua;Shen, Min;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Zhou, Ping;Wan, Peng-Cheng;Zhang, Yun-Sheng;Gao, Lei;Yang, Jing-Quan;Pi, Wen-Hui;Wang, Xin-Hua;Shen, Min;Yang, Hua;Yang, Yong-Lin;Liu, Chang-Bin;Zhou, Ping;Wan, Peng-Cheng;Zhang, Yun-Sheng;Gao, Lei;Yang, Jing-Quan;Pi, Wen-Hui;Wang, Xin-Hua;Liu, Guang-Jian;Ren, Yan-Ling;Shen, Zhi-Qiang;Wang, Feng;Deng, Juan;Hehua, Eer;Esmailizadeh, Ali;Dehghani-Qanatqestani, Mostafa;Tpnek, Ondej;Weimann, Christina;Erhardt, Georg;Amane, Agraw;Amane, Agraw;Hanotte, Olivier;Mwacharo, Joram M.;Han, Jian-Lin;Han, Jian-Lin;Hanotte, Olivier;Hanotte, Olivier;Lenstra, Johannes A.;Kantanen, Juha;Coltman, David W.;Kijas, James W.;Bruford, Michael W.;Bruford, Michael W.;Periasamy, Kathiravan

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2020 年 11 卷 1 期

页码：

收录情况： SCI

摘要： Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals. Genetic resources for livestock are valuable for understanding their demography and past selection, and may inform future breeding programs and agricultural improvement. Here, the authors present deep resequencing of 248 wild and domestic sheep, with associated data and analysis.

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