The pH-Sensitive Potassium Channel TASK-1 Is a Chemosensor for Central Respiratory Regulation in Rats
文献类型： 外文期刊
第一作者： Li, Q. Q.
作者： Li, Q. Q.;Wan, K. X.;Wang, C. T.;Mao, F. X.;Zhu, J. L.;Pan, Z. M.;Gao, R.;Xu, M. S.;Wang, L. M.;Zhang, Y. Y.
作者机构：
关键词： TASK-1; respiratory center; central chemoreceptors; AEA; respiratory regulation
期刊名称：MOLECULAR BIOLOGY （ 影响因子：1.374； 五年影响因子：1.266 ）
ISSN： 0026-8933
年卷期： 2020 年 54 卷 3 期
页码：
收录情况： SCI
摘要： TWIK-related acid-sensitive potassium channel-1 (TASK-1) is a "leak" potassium channel sensitive to extracellular protons. It contributes to setting the resting potential in mammalian neurons. TASK-1 channels are widely expressed in respiratory-related neurons in the central nervous system. Inhibition of TASK-1 by extracellular acidosis can depolarize and increase the excitability of these cells. Here we describe the distribution of TASK-1 in the rat brainstem and show that TASK-1 mRNAs are present in respiratory-related nuclei in the ventrolateral medulla, which have been proposed as neural substrates for central chemoreception in rats. After inhalation of 8% CO(2)for 30 and 60 min, TASK-1 mRNA levels in positive-expression neurons were remarkably upregulated. Injection of the TASK-1 blocker anandamide (AEA) into the rat lateral cerebral ventricle, showed a significant excitement of respiratory at 10 min posttreatment, with a marked decrease in inspiratory and expiratory durations and an increased frequency of respiration. We suggest that TASK-1 channel may serve as a chemosensor for in central respiration and may contribute to pH-sensitive respiratory effects. TASK-1 channel might be an attractive candidate for sensing H+/CO(2)in several respiratory-related nuclei in the brainstem. It is likely that TASK-1 participates in pH-sensitive chemical regulation in the respiratory center under physiological and pathological conditions.
分类号：
- 相关文献
作者其他论文 更多>>
-
ToxR modulates biofilm formation in fish pathogen Vibrio harveyi
作者：Zhang, Y.;Deng, Y.;Feng, J.;Hu, J.;Chen, H.;Guo, Z.;Su, Y.;Zhang, Y.;Hu, J.;Chen, H.;Gao, R.;Su, Y.
关键词：biofilm formation; gene knockout; phenotypic characterization; toxR; Vibrio harveyi
-
INCREASING INVASION RISK FROM THE NORTHWARD EXPANSION OF LARGEMOUTH BASS (MICROPTERUS SALMOIDES) IN CHINA UNDER MULTIPLE INFLUENCES
作者：Fang, K.;Xu, Q. Q.;Zhang, H.;Fang, K.;Zhang, Y. Y.;Shen, L.;Zhou, Q.;Zhang, H.;Shao, J.;Gorfine, H.
关键词：largemouth bass; non-native aquatic species; habitat suitability curve; potential spawning; area; multiple influences; biological invasion
-
EFFECTS OF MAIZE (ZEA MAYS L.) INTERCROPPING WITH LEGUMES ON NITROUS OXIDE (N2O) EMISSIONS
作者：Chen, J. S.;Amin, A. S.;Hamani, A. K. M.;Wang, G. S.;Zhang, Y. Y.;Gao, Y.;Chen, J. S.;Amin, A. S.;Hamani, A. K. M.;Liu, K.
关键词：soybean; peanut; global warming potential; nitrogen rate; cumulative N2O emissions
-
Isolation, expression, and microRNAs analysis of genes related to carotenoid metabolism in peach fruits
作者：Zhang, C. H.;Ma, R. J.;Zhang, Y. Y.;Yu, M. L.
关键词：
-
Characterization of gamma-Radiation-Induced DNA Polymorphisms in the M1 Population of the Japonica Rice Variety Gaogengnuo by Whole-Genome Resequencing
作者：Zhang, L.;Xie, H. K.;Zhang, Y. H.;Zhang, Y. Y.;Yang, Zh.;Sun, P. Y.;Peng, X. M.
关键词：rice; radiation; genome resequencing; InDels; SNPs; CNVs
-
The establishment of a practical method for the determination of piperazine residues using accelerated solvent extraction and UHPLC-FLD
作者：Guo, Y. W.;Zhang, Y. Y.;Xie, K. Z.;Bu, X. N.;Liu, C. J.;Zhang, T.;Zhang, G. X.;Dai, G. J.;Guo, Y. W.;Wang, B.;Zhang, Y. Y.;Xie, K. Z.;Bu, X. N.;Liu, C. J.;Zhang, T.;Zhang, G. X.;Liu, X. Z.;Dai, G. J.;Xie, X.;Wang, B.;Liu, X. Z.
关键词：piperazine; ASE; derivatisation; UHPLC-FLD
-
Genome sequencing of Acinetobacter radioresistens LY strain and XF strain, isolated from peanut bacterial wilt nursery
作者：Wu, Q.;Wang, Z. W.;Wang, X. Z.;Tang, Y. Y.;Song, G. S.;Wang, C. T.;Chen, J. H.;Wu, C. Z.
关键词：
