Accumulation and Elimination of Tetrodotoxin in the PufferfishTakifugu obscurusby Dietary Administration of the Wild Toxic GastropodNassarius semiplicata

文献类型： 外文期刊

第一作者： Zhang, Xiaojun

作者： Zhang, Xiaojun;Chen, Si;Xu, Hanxiang;Zhang, Xiaojun;Chen, Si;Zong, Jingjing;Lu, Yibo;Wang, Ruirui;Xu, Hanxiang;Li, Menglong

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关键词： tetrodotoxin; Takifugu obscurus; accumulation; elimination; Nassarius semiplicata

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

ISSN：

年卷期： 2020 年 12 卷 5 期

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收录情况： SCI

摘要： To investigate pufferfish accumulation, elimination, and distribution of tetrodotoxin (TTX),Takifugu obscuruswas fed with wild TTX-containing gastropodNassarius semiplicatato simulate the natural food chain. Three-month-old non-poisonousT. obscuruswas fed with wild toxicN. semiplicataat three exposure dose for 28 days, and later, with toxin-free food until day 67. Three fish individuals from each treatment were sampled, and the distribution of TTX in different tissues was measured. The results showed that the accumulation ratio of TTX in the three exposure dose groups ranged from 35.76% to 40.20%. The accumulation ratio in the skin and liver was the highest amongst all tissues, accounting for more than 85% of the total TTX, whereas that in the kidney and gallbladder was the lowest (0.11-0.78%). Studies on the kinetic of TTX accumulation and elimination revealed that the skin was the tissue with the highest accumulation speed constant (8.06), while the liver, kidney, and intestinal tract showed the highest speed of TTX elimination. The time required for TTX reduction to reach the safety limit could be predicted by using standard elimination equations. Qualitative analysis by UPLC-MS/MS revealed the occurrence of seven TTX derivatives inT. obscurus; of these TTX, 5-deoxy TTX, 11-deoxy TTX, 4,9-anhydro TTX were found in all tested tissues.

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