Effect of chitooligosaccharides on human gut microbiota and antiglycation

文献类型： 外文期刊

第一作者： Liu, Wei

作者： Liu, Wei;Pi, Xionge;Fei, Dibo;Wang, Xin;Li, Xiaoqiong;Liu, Daqun;Zhao, Zhonglin;Meng, Yanyu

作者机构：

关键词： AGEs; Antiglycation; Chitooligosaccharides; Gut microbiota; Prebiotics; SCFA

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2020 年 242 卷

页码：

收录情况： SCI

摘要： Chitooligosaccharides (COS) have garnered great attention in the field of human healthcare. The prebiotic activities and antiglycation of COS were investigated using a combination of in vitro and in vivo studies. COS supplementation dramatically increased the levels of acetic acid, while reducing the concentrations of propionic and butyric acids. It also decreased the total bacterial population; however, it did not affect diversity and richness of the gut microbiota. In addition, COS modulated the gut microbiota composition by increasing Bacteroidetes, decreasing Proteobacteria and Actinobacteria, and lowering the Firmicutes/Bacteroidetes ratio. COS promoted the generation of beneficial Bacteroides and Faecalibacterium genera, while suppressing the pa- thogenic Klebsiella genus. The antiglycation activity of COS and acetic acid was dose-dependent. Furthermore, COS prevented the decrease of serum N ?-(carboxymethyl) lysine (CML) level caused by CML ingestion in a mouse model of diet-induced obesity. To improve host health, COS could be potential prebiotics in food products.

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