Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulatingAKTandCREBin rats

文献类型： 外文期刊

第一作者： Ahmed, Ayaz

作者： Ahmed, Ayaz;Azhar, Mudassar;Lin, Haiying;Zhang, Mijia;Zhang, Hong;Yang, Sijin;Liu, Xinmin;Wang, Qiong;Ahmed, Ayaz;Zeng, Guirong;Azhar, Mudassar;Jiang, Dejian;Ahmed, Ayaz;Zeng, Guirong;Azhar, Mudassar;Jiang, Dejian;Ahmed, Ayaz;Azhar, Mudassar;Choudhary, Muhammad Iqbal;Zeng, Guirong;Liu, Xinmin;Wang, Fengzhong;Wang, Qiong;Farooq, Ahsana Dar;Choudhary, Muhammad Iqbal

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关键词： diabetes-associated cognitive decline; Morris water maze; protein kinase B (Akt) and cAMP response element binding protein (CREB); reference and working memory

期刊名称：PHYTOTHERAPY RESEARCH （ 影响因子：5.878； 五年影响因子：5.286 ）

ISSN： 0951-418X

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收录情况： SCI

摘要： Memory loss is a complication of diabetes which requires new approaches to its treatment. Shengmai San (SMS) is a famous traditional Chinese formula containingPanax ginseng,Ophiopogon japonicas, andSchisandra chinensis, whereas Radix puerariae has many reported pharmacological uses. In this study the combination, as Jiawei SMS (J-SMS) was screened for its ability to reverse diabetes-associated cognitive decline in rats. This was assessed behaviorally in diabetic rats (Streptozotocin, 45 mg/kg), with biochemical and western blot analysis (Akt and CREB). Diabetic rats showed fasting blood glucose (FBG) in the range of 13-15 mM throughout the study. J-SMS (0.5, 1.5, 4.5 g/kg) treatment significantly improved learning and memory deficit among diabetic rats as evidenced by preference for novel object, reduced escape latency and increased number of platform crossings (p< .05) in the NORT and MWM tests. Treatment with J-SMS also significantly improved the histopathological changes in the diabetic brain and increased the protein expression of AKT and CREB, required for proper memory function (p< .01). This study highlighted that J-SMS can reverse reference and working memory deficit among diabetic rats by modulating AKT and CREB proteins activation. Thus, J-SMS formulation might be possible candidate for further development.

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