Transcriptome analysis of Takifugu obscurus liver in response to acute retene exposure

文献类型： 外文期刊

第一作者： Jiang, Shulun

作者： Jiang, Shulun;Fang, Di-an;Xu, Dongpo

作者机构：

关键词： Alkyl-PAH; KEGG pathway; hepatic toxicity; anadromous; molecular mechanism

期刊名称：JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING （ 影响因子：2.269； 五年影响因子：2.108 ）

ISSN： 1093-4529

年卷期： 2020 年 55 卷 10 期

页码：

收录情况： SCI

摘要： Retene (1-methyl-7-isopropyl-phenanthrene, RET) is an alkyl polycyclic aromatic hydrocarbon (PAH) with environmental risk to aquatic animals.Takifugu obscurusis a migratory fish species with high economic and ecological value. To assess the toxic effects of RET on molecular metabolism, juvenileT. obscurusin this study were acutely exposed to 44.30 mu g/L of RET for four days. The transcriptome profiles of livers were compared between RET treatment group and the control, and the results revealed that 1,897 genes were significantly differentially expressed (DEGs) after exposure to RET, which enriched 17 KEGG pathways. Among these, glycerolipid metabolism, glycerophospholipid metabolism, insulin signaling pathway, and FOXO signaling pathways were significantly activated. Further exploration indicated that RET exposure disrupted glucose metabolism, stimulated insulin metabolism, and activated cell proliferation genes. Overall, these findings help explain the molecular mechanisms underlying RET toxicity, and may offer evidence to supportT. obscurusprotection.

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