Preparative purification of corilagin fromPhyllanthusby combining ionic liquid extraction, prep-HPLC, and precipitation

文献类型： 外文期刊

第一作者： Hou, Xiaodong

作者： Hou, Xiaodong;Cheng, Zitao;Wang, Jiao

作者机构：

期刊名称：ANALYTICAL METHODS （ 影响因子：2.896； 五年影响因子：2.716 ）

ISSN： 1759-9660

年卷期： 2020 年 12 卷 26 期

页码：

收录情况： SCI

摘要： In this study, a green extraction and purification process for the rapid preparation of corilagin fromPhyllanthushas been designed using an aqueous ionic liquid coupled with preparative high-performance liquid chromatography (prep-HPLC) and precipitation. The results showed that the optimum extraction process for corilagin involved mixingPhyllanthus tenellusRoxb. with 0.4 M [BMIm]Br at a liquid-solid ratio of 10 : 1 and dispersing the mixture by ultrasonication at 50 degrees C for 15 min. Macroporous resin D101 and prep-HPLC were employed for [BMIm]Br removal and corilagin separation to yield corilagin of 86.49% purity. Subsequently, corilagin was further purified by water precipitation to achieve 99.12% purity. The results indicated the successful development of a new rapid and green process to prepare corilagin on a large scale from plants using [BMIm]Br. This promising process can be applied for the preparative separation and purification of other active compounds from complex plant systems.

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