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Peptides YYGGEGSSSEQG and SESEM Inhibit TNF-alpha-Induced Smooth Muscle Cells Proliferation and Migration Through Their Bindings to TNF-alpha Receptor

文献类型：外文期刊

第一作者： Geng, Dong-Hui

作者： Geng, Dong-Hui;Ju, Zhiyuan;Xiao, Tianzhen;Zhou, Sumei;Huang, Lu;Liu, Liya;Zhou, Xianrong;Wang, Lili;Tong, Li-Tao

作者机构：

关键词： Peptides; VSMCs; Proliferation; Migration; TNF-alpha receptor

期刊名称：INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS （影响因子：1.931；五年影响因子：1.712 ）

ISSN： 1573-3149

年卷期：

页码：

收录情况： SCI

摘要： The peptides YYGGEGSSSEQG and SESEM derived from rice alpha-globulin have been reported to possess anti-atherosclerotic activity, but the role in the proliferation and migration of vascular smooth muscle cell (VSMC) and the underlying mechanisms remain unknown. In the present study, we observed the effects of the peptides YYGGEGSSSEQG and SESEM on VSMC proliferation and migration, and a computer simulated interaction between the peptides and TNF-alpha. The peptides might effectively inhibit TNF-alpha-induced VSMC proliferation and migration or promote its apoptosis by promoting the expression of transforming growth factor-beta (TGF-beta) and suppressing the expression of platelet-derived growth factor (PDGF) BB proteins. In addition, the binding energy of YYGGEGSSSEQG to TNF-alpha receptor 1 (TNFR1) was lower than that of endogenous RMP16 with high activity. Therefore, the peptide inhibited the activity of TNF-alpha by binding to TNFR1. These results demonstrated that the peptides YYGGEGSSSEQG and SESEM reduced TNF-alpha-induced smooth muscle cell proliferation and migration or increased its apoptosis by promoting the activity of TGF-beta and inhibiting the activities of PDGF-BB and TNF-alpha.

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