Effect of Chinese Herbal Medicines Supplementation on the Diversity and Structure of Intestinal Microbiota in Broiler Cecum

文献类型： 外文期刊

第一作者： Fu, Chunyan

作者： Fu, Chunyan;Zhang, Yan;Wei, Xiangfa;Shi, Tianhong;Yan, Peipei;Liu, Xuelan;Fu, Chunyan;Zhang, Yan;Wei, Xiangfa;Shi, Tianhong;Yan, Peipei;Liu, Xuelan;Fu, Chunyan;Zhang, Yan;Wei, Xiangfa;Shi, Tianhong;Yan, Peipei;Liu, Xuelan;Yao, Qimeng

作者机构：

关键词： Chinese herbal medicines; Broiler; Intestinal microbiota; Cecum; Antibiotic alternative; 16S rRNA sequencing

期刊名称：INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY （ 影响因子：0.822； 五年影响因子：0.906 ）

ISSN： 1560-8530

年卷期： 2020 年 24 卷 1 期

页码：

收录情况： SCI

摘要： The excessive use of antibiotics disrupts the balance of normal microflora, and stimulates the development of drug-resistant bacteria, which threaten not only the human health but also the environment. This study was conducted to provide some insights into the effect of different Chinese herbal medicines (CHM) supplementation on the diversity and composition of broilers intestinal microbiota by high-throughput sequencing. A total of 420 one-day-old Arbor Arbor broilers were divided into seven groups: fed basal diet (CT), or basal diet supplemented with 0.1% monensin (MON), Cynanchum atratum Bunge (CA), Radices paeoniae alba (RPA), Morus alba L. (MAL), Astragalus membranaceus (AM), or Eucommia ulmoides Oliver (EUO) for 42 days. The intestinal microbiota of the cecum was analyzed by high-throughput sequencing (16S rRNA genes). Taxonomic components of intestinal microbiota revealed that the cecum microbiota of CHM groups was clearly distinguished from the MON and CT groups. CHM significantly influenced the relative abundances of ceca microbiota genera at phylum and genus level via increasing the abundance of beneficial bacterial and decreasing the colonization of pathogens, especially in CA, EUO, RPA and MAL groups. Functional profiling of bacterial communities revealed that CHM increased the enrichment of several functional categories, such as cellular processes, metabolism, organismal systems and immune system. In conclusion, the present study showed that CHM influenced the diversity and taxonomic composition of broiler ceca microbiota, and the functional categories were clearly disparate. These results improved our comprehension of the influence of CHM on structure and activity of intestinal microbiota in broiler, and contributed to the development of antibiotic alternative feeding strategies. (C) 2020 Friends Science Publishers

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