Antifungal Nafuredin and Epithiodiketopiperazine Derivatives From the Mangrove-Derived FungusTrichoderma harzianumD13

文献类型： 外文期刊

第一作者： Zhao, Dong-Lin

作者： Zhao, Dong-Lin;Zhang, Xi-Fen;Huang, Rui-Huan;Wang, Dan;Wang, Xiao-Qiang;Li, Yi-Qiang;Zhang, Peng;Zhang, Cheng-Sheng;Wang, Dan;Zheng, Cai-Juan

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关键词： nafuredins; epithiodiketopiperazines; Magnaporthe oryzae; antifungal activity; Trichoderma harzianum

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： A new polyketide derivative, nafuredin C (1), a novel heterocyclic dipeptide, trichodermamide G (3), together with four known biogenetically related compounds nafuredin A (2), trichodermamide A (4), aspergillazin A (5), and peniisocoumarin H (6), were isolated from the mangrove-derived fungusTrichoderma harzianumD13. Their structures, including their absolute configurations, were determined by spectroscopic analysis and time-dependent density functional theory-electronic circular dichroism (ECD) calculations. Trichodermamide G was found to be a novel epithiodiketopiperazine derivative with an unprecedented cyclic system containing a sulfur bridge, and nafuredin C represented the third nafuredin derivative of these homologous compounds. The new compound nafuredin C exhibited obvious antifungal activity againstMagnaporthe oryzaewith a minimum inhibitory concentration (MIC) of 8.63 mu M, which is on the same order of magnitude as the positive control carbendazim (MIC = 3.27 mu M).

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