Antiviral responses of ATG13 to the infection of peste des petits ruminants virus through activation of interferon response

文献类型： 外文期刊

第一作者： Ma, Peng

作者： Ma, Peng;Jin, Li;Zhang, Derong;Cao, Xin;Guo, Fucheng;Zhao, Yongqing;Bai, Jialing;Ma, Zhongren;Ma, Xiao-xia;Li, Lingxia;Shang, Youjun

作者机构：

关键词： Autophagy-related proteins; ATG13; PPRV; Interferon; Interferon-stimulated genes

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN： 0378-1119

年卷期： 2020 年 754 卷

页码：

收录情况： SCI

摘要： Not only are autophagy-related (ATG) proteins the essential orchestrators of the autophagy machinery, but also they regulate many other cellular pathways. Here, we demonstrated that ATG13 exerted an obviously antiviral activity against the infection of peste des petits ruminants virus (PPRV) in cell culture model. We found that PPRV infection or the treatment with interferon (IFN) against PPRV infection significantly induced ATG13 expression. Mechanistically, ATG13 stimulated interferon expression and the subsequent activation of the JAK-STAT cascade. These activations triggered the transcription of interferon-stimulated genes (ISGs) to exert antiviral activity. Conversely, the loss of ATG13 significantly attenuated the potency of RIG-IN in activating IFN responses. In summary, we have demonstrated that basal ATG13 was involved in host antiviral activities against PPRV infection and the over-expression of ATG13 activated IFN production to inhibit PPRV replication in an unconventional fashion.

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