Modulation of cecal microbiota in laying hens via intake of genetically modified corn with themaroACCormCry1Acgenes

文献类型： 外文期刊

第一作者： Zhong, Ruqing

作者： Zhong, Ruqing;Zhang, Lilan;Chen, Liang;Zhang, Hongfu;Yang, Xiaoguang

作者机构：

关键词： maroACC; mCry1Ac; cecal microbiota; transgenic; safety

期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：3.638； 五年影响因子：3.802 ）

ISSN： 0022-5142

年卷期： 2020 年 100 卷 15 期

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收录情况： SCI

摘要： BACKGROUND The present study investigated the chronic effect on the composition and proportions of the cecal microbiota of laying hens for 12 weeks after consuming two genetically modified (GM) corns containing themaroACCgene from theAgrobacterium tumefaciensstrain (CC) and themCry1Acgene from theBacillus thuringiensisstrain (BT) in comparison with the isogenic corn (CT). RESULTS In total, 72 hens were randomly assigned to the CT corn-based diet, CC corn-based diet and BT corn-based diet. The absolute weights of abdominal fat, breast, thigh meat and organ weight were not affected by the dietary treatment. High-throughput 16S rRNA gene sequencing revealed a few differences in the composition of cecal microbiota among the treatments. The only difference with respect to bacterial family was that the cecal abundance ofPorphyromonadaceae(3.46versus2.11%;P= 0.073) tended to be higher for birds consuming the CC diet than those birds consuming the CT diet. Birds fed the BT diet tended to have a higher abundance ofBarnesiella(0.62versus0.13%;P= 0.057) and a lower abundance ofunclassified Ruminococcaceae(0.64versus1.19%;P= 0.097) than those fed the CT diet. Considering beneficial intestinalBarnesiella, this decreases and ultimately clears the colonization of vancomycin-resistantEnterococcus. Theunclassified Ruminococcaceaewas a low-frequency and low-abundance bacterial taxa and was not associated with intestinal pathology. CONCLUSION These results indicate a similar modulation of cecal microbiota in laying hens by long-term feeding among transgenic CC corn, BT corn and non-transgenic corn and provide data for biosafety evaluation of the transgenic corn. (c) 2020 Society of Chemical Industry

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