文献类型： 外文期刊

第一作者： Zhang Hao-Wen

作者： Zhang Hao-Wen;Cao Hao;Wang Yu-Lu;Xin Feng-Jiao

作者机构：

关键词： human gut microbiota; glycoside hydrolases; glycosyltransferases; polysaccharide lyases; carbohydrate esterases; auxiliary activities

期刊名称：PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS （ 影响因子：0.351； 五年影响因子：0.272 ）

ISSN： 1000-3282

年卷期： 2020 年 47 卷 7 期

页码：

收录情况： SCI

摘要： The human gut microbiota is a metabolic organ that plays an essential role in human health and disease. The molecular mechanisms of its involvement in processes such as host food digestion, immunity and brain function are the synergistic coupling of specific metabolic pathways between microorganism and human. Enzymes are the basic functional units that involved in the transformation of substances in the metabolic pathways. An in-depth look into the catalytic mechanisms of the enzymes encoded by human gut microbiota will provide a theoretical framework for exploring the interventions of precision nutrition and medicine targeting the human gut microbiota (or intestinal enzymes). Studies on enzymatic hydrolysis of specific substrates have shown that the human gut microbiota not only encodes all known families of carbohydrate active enzymes (CAZYmes), but also contains plenty of the potentially novel CAZYmes. This paper describes the principles of classification and catalytic properties of CAZYmes, and mainly reviews the research progresses on the crystal structures of novel CAZYmes derived from the human gut microbiota.

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