African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3

文献类型： 外文期刊

第一作者： Wang, Yang

作者： Wang, Yang;Cui, Shuai;Xin, Ting;Yu, Hainan;Chen, Shiyu;Jiang, Yajun;Jiang, Yitong;Guo, Xiaoyu;Jia, Hong;Zhu, Hongfei;Wang, Xixi;Gao, Xintao

作者机构：

关键词： African swine fever virus; interferon; IRF3; ubiquitination; immune evasion

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：6.073； 五年影响因子：6.34 ）

ISSN： 2235-2988

年卷期： 2022 年 11 卷

页码：

收录情况： SCI

摘要： African swine fever (ASF) is a devastating infectious disease caused by African swine fever virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that contribute to evasion of host immunity. In this study, we determined that the viral non-structural protein MGF360-14L inhibits interferon-beta (IFN-beta) promoter activity induced by cGAS-STING signaling. MGF360-14L was also found to downregulate expression of the IRF3 protein and promote its degradation through ubiquitin-meditated proteolysis. Moreover, MGF360-14L was shown to interact with and destabilize IRF3 by facilitating E3 ligase TRIM21-mediated K63-linked ubiquitination of IRF3. Overall, our study revealed that MGF360-14L promotes degradation of IRF3 through TRIM21, thereby inhibiting type I interferon production. These findings provide new insights into the mechanisms underlying ASFV immune evasion.

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