Detection of the 23-bp nucleotide sequence mutation in retinoid acid receptor related orphan receptor alpha(RORA)gene and its effect on sheep litter size

文献类型： 外文期刊

第一作者： Yang, Yuta

作者： Yang, Yuta;Hu, Huina;Lan, Xianyong;Pan, Chuanying;Mao, Cui;Lu, Xiaofang;Han, Xufei;Hao, Kunjie;Zhang, Qingfeng;Mao, Cui;Jiang, Fugui

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关键词： Sheep; retinoid acid receptor related orphan receptor alpha (RORA); Insertion; deletion (Indel); mutation; litter size

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： Retinoid acid receptor related orphan receptor alpha (RORA) transcribes steroid-related genes to regulate estrogen synthesis. As an important reproductive trait, litter size relates to estrogen synthesis. Therefore, it is important to investigate the association betweenRORAgene and sheep litter size. In this study, one 23-bp nucleotide sequence mutation was identified in intron 1 ofRORAgene in 532 female Australian White Sheep. Moreover, the polymorphic information content (PIC) values of this locus was 0.219. The litter size of ID genotype was significantly better than II genotype and DD genotype in the second born litter size (p < 0.05). This loci was related to third born litter size and the ID is the dominant genotype (p < 0.05). The association between combined genotypes and average litter size showed that sheep with heterozygote (ID) genotypes had larger lamb than homozygous (DD and II) genotypes. To sum, this study provided theoretical references for the comprehensively research of the function ofRORAgene and the breeding of Australian White Sheep. The 23-bp indel variants could be considered as molecular markers for the second and third born litter size of sheep for MAS breeding.

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