The correlated expression of immune and energy metabolism related genes in the response to Salmonella entericaser ovar Enteritidis inoculation in chicken

文献类型： 外文期刊

第一作者： Wang, Yuanmei

作者： Wang, Yuanmei;Miao, Xiuxiu;Li, Huilong;Su, Pengcheng;Lin, Lili;Li, Xianyao;Wang, Yuanmei;Liu, Liying

作者机构：

关键词： Salmonella entericaserovar Enteritidis; Chicken; Energy metabolism; Immune; Gene expression

期刊名称：BMC VETERINARY RESEARCH （ 影响因子：2.741； 五年影响因子：2.955 ）

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年卷期： 2020 年 16 卷 1 期

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收录情况： SCI

摘要： Background Salmonella entericaserovar Enteritidis (SE) is one of the food-borne pathogenic bacteria, which affects poultry production and poses severe threat to human health. The correlation of immune system and metabolism in chicken after SE inoculation is important but not clear. In the current study, we identified the expression of immune and energy metabolism related genes using quantitative PCR to evaluate the correlation between immune system and energy metabolism against SE inoculation in Jining Bairi chicken. Results ATP5G1, ATP5G3 and ND2 were significantly up-regulated at 1 dpi (day post inoculation), and ATP5E, ATP5G1, ATP5G3 were significantly down-regulated at 7 dpi (P < 0.05). IL-8 and IL-1 beta were significantly down-regulated at 1 dpi, IL-8 and IL-18 were significantly down-regulated at 3 dpi, IL-8 and BCL10 were significantly up-regulated at 7 dpi (P < 0.05). Conclusions These findings indicate that the correlation between immune and energy metabolism related genes gradually change with time points post SE inoculation, from one homeostasis to an opposite homeostasis with 3 dpi as a turning point. These results will pave the foundation for the relationship between immune system and energy metabolism in the response to SE inoculation in chicken.

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