Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway

文献类型： 外文期刊

第一作者： Ma, Yanhong

作者： Ma, Yanhong;Li, Yahui;Zhang, Hongzhi;Wang, Ying;Huang, Wuyang;Ma, Yanhong;Huang, Wuyang;Wu, Caie;Huang, Wuyang

作者机构：

关键词： apoptosis; endoplasmic reticulum stress; hepatic stellate cells; malvidin; mitochondrial pathways

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：2.863； 五年影响因子：3.141 ）

ISSN： 2048-7177

年卷期： 2020 年 8 卷 9 期

页码：

收录情况： SCI

摘要： Blueberries have great beneficial effects due to high level of anthocyanins, especially malvidin. Hepatic stellate cells (HSCs) can be activated and increase excessive extracellular matrix (ECM) components, which play a central role in liver fibrogenesis. Therefore, activated HSC's apoptosis can be induced to recover liver fibrosis. Malvidin's effects on apoptosis in rat activated hepatic stellate T6 cells (HSC-T6) in vitro were investigated here. High concentration of malvidin was found to significantly induce apoptosis, activate caspase-3, increase malondialdehyde, upregulate Bax, but downregulate Bcl-2. Moreover, malvidin upregulated the protein levels of some endoplasmic reticulum stress (ERS)-typical markers, including caspase-12, glucose-regulated protein 78 (GRP78), and CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), suggesting that malvidin induced HSC apoptosis by the ERS apoptosis pathway as well as the mitochondrial-dependent pathway. These findings indicated that blueberry anthocyanins, especially malvidin, could induce activated hepatic stellate cell apoptosis and might act as one kind of functional food ingredient or a novel nutraceutical beneficial for liver health.

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