Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2

文献类型： 外文期刊

第一作者： Shahrajabian, Mohamad Hesam

作者： Shahrajabian, Mohamad Hesam;Sun, Wenli;Cheng, Qi;Cheng, Qi;Cheng, Qi

作者机构：

关键词： SARS; coronaviruses; SARS-CoV-2; MERS; pneumonia; emerging diseases

期刊名称：HUMAN VACCINES & IMMUNOTHERAPEUTICS （ 影响因子：3.452； 五年影响因子：3.483 ）

ISSN： 2164-5515

年卷期：

页码：

收录情况： SCI

摘要： SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae. SARS-CoV-2 entry to cellsis initiated by the binding of the viral spike protein (S) to its cellular receptor. The roles of S protein in receptor binding and membrane fusion makes it a prominent target for vaccine development. SARS-CoV-2 genome sequence analysis has shown that this virus belongs to the beta-coronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. A vaccine should induce a balanced immune response to elicit protective immunity. In this review, we compare and contrast these three important CoV diseases and how they inform on vaccine development.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序