A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken

文献类型： 外文期刊

第一作者： Huang, Tao

作者： Huang, Tao;Sheng, Zheya;Song, Chi;Hu, Xiaoxiang;Huang, Tao;Pu, Yuejin

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关键词： yellow plumage color; genome-wide association; linkage analysis

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

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年卷期： 2020 年 99 卷 6 期

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收录情况： SCI

摘要： Chicken plumage color is an important economical trait in poultry breeding, as triple-yellow indigenous broilers are preferred over western commer-cial broilers in the Chinese market. However, the studies on the pigmentation of plumage coloration are relatively rare at present. Here, we performed a genome-wide mapping study on an F2 intercross, whose 2 founders were one hybrid commercial line "High Quality chicken Line A" that originated from the Anak red chicken and one indigenous line "Huiyang Beard" chicken that is a classical "triple-yellow" Chinese indigenous breed. Moreover, we used an automatic colorimeter that can quantitatively assess the colorations in L*, a*, and b* values. One major quantitative trait locus (QTL) on chromosome 2 was thus identified by both genome-wide association and linkage analyses, which could explain 10 to 20% of the total phenotypic variance of the b* mea-surements of the back plumage color. Using linkage analysis, 2 additional QTL on chromosome 1 and 20 were also found to be significantly associated with the plumage coloration in this cross. With additional sam-ples from Anak red and Huiyang Beard chickens as well as pooled resequencing data from the 2 founders of this cross, we then further narrowed down the QTL regions and identified several candidate genes, such as CA-BLES1, CHST11, BCL2L1, and CHD22. As the effects of QTL found in this study were substantial, quantitatively measuring the coloration rather than the descriptive measurements provides stronger statistical power for the analyses. In addition, this major QTL on chromosome 2 that was associated with feather pigmentation at the genome-wide level will facilitate the future chicken breeding for yellow plumage color. In conclusions, we mapped 3 associated QTL on chromosome 1, 2, and 20. The candidate genes identified in this study shed light in the genetic basis of yellow plumage color in chicken.

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