Detection of InDel and CNV ofSPAG17gene and their associations with bovine growth traits

文献类型： 外文期刊

第一作者： Guo, Xian

作者： Guo, Xian;Pei, Jie;Wu, Xiaoyun;Bao, Pengjia;Ding, Xuezhi;Xiong, Lin;Chu, Min;Yan, Ping;Guo, Xian;Pei, Jie;Wu, Xiaoyun;Bao, Pengjia;Ding, Xuezhi;Xiong, Lin;Chu, Min;Yan, Ping;Lan, Xianyong

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关键词： Cattle; SPAG17; insertions; deletions (indels); copy number variations (CNVs); growth traits

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.282； 五年影响因子：1.702 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： Sperm-associated antigen 17 (SPAG17) gene encodes a central pair protein, which is involved in flagellar motility, male fertility and skeletal growth in ruminants. The insertions/deletions (indels) and copy number variations (CNVs) influence phenotypic traits by altering the sequences and copy numbers of functional genes, respectively. This study identified a novel 8-bp indel ofSPAG17gene in 1520 individuals from eight different cattle breeds, as well as a novel CNV region in 355 animals. The correlation analysis of indel showed that the individuals of ID genotype had superior performance traits such as body height (p = 0.038) and body slanting length (p = 0.041) as compared to other genotypes in Xianan cattle. For the CNV, different copy numbers were closely related to the body height in Qinchuan (p = 0.045) and body weight in Xianan (p = 0.036) breeds. Importantly, significant difference was observed between the 8-bp indel and the copy number loss in Xianan breed (p < 0.01). These findings indicated that the variations within the bovineSPAG17gene can be considered as an effective DNA molecular marker for beef cattle breeding.

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