Long-Term Consumption of 2-O-beta-D-Glucopyranosyl-L-ascorbic Acid from the Fruits of Lycium barbarum Modulates Gut Microbiota in C57BL/6 Mice

文献类型： 外文期刊

第一作者： Dong, Wei

作者： Dong, Wei;Huang, Kaiyin;Wan, Peng;Peng, Yujia;Zeng, Xiaoxiong;Yan, Yamei;Cao, Youlong;Yan, Yamei;Cao, Youlong

作者机构：

关键词： Lycium barbarum; 2-O-beta-D-glucopyranosyl-L-ascorbic acid; modulation effect; gut microbiota

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2020 年 68 卷 33 期

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收录情况： SCI

摘要： The modulating effect of 2-O-beta-D-glucopyranosyl-L-ascorbic acid (AA-2 beta G), a natural derivative of ascorbic acid from the fruits of Lycium barbarum, on mice gut microbiota was investigated in the present study. It was found that AA-2 beta G was able to adjust the structure of mice gut microbiota, elevated the relative abundances of Verrucomicrobia, Porphyromonadaceae, Verrucomicrobiaceae, and Erysipelotrichaceae, and meanwhile reduced the relative abundances of Firmicutes, Lachnospiraceae, Rikenellaceae, Ruminococcaceae, Bdellovibrionaceae, Anaeroplasmataceae, and Peptococcaceae. Through the linear discriminant analysis effect size analysis, the key microbiota that were found to be significantly changed after long-term consumption of AA-2 beta G were Ruminococcaceae, Porphyromonadaceae, Lachnospiraceae, and Rikenellaceae. In addition, AA-2 beta G could upregulate pro-inflammatory cytokines, promote tight junctions between intestinal cells, facilitate the generation of short-chain fatty acids (SCFAs), and upregulate the mRNA expression level of SCFAs receptors, indicating that AA-2 beta G might promote organism health. The results demonstrated that AA-2 beta G might maintain organism health by modulating gut microbiota.

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