Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers

文献类型： 外文期刊

第一作者： Syed, Tahira

作者： Syed, Tahira;Askari, Muhammad;Meng, Zhigang;Li, Yanyan;Abid, Muhammad Ali;Wei, Yunxiao;Guo, Sandui;Liang, Chengzhen;Zhang, Rui

作者机构：

关键词： Bacillus thuringiensis; vegetative insecticidal proteins; insecticidal activity; resistance; pyramids

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

ISSN：

年卷期： 2020 年 12 卷 8 期

页码：

收录情况： SCI

摘要： Bacillus thuringiensis(Bt) is a Gram negative soil bacterium. This bacterium secretes various proteins during different growth phases with an insecticidal potential against many economically important crop pests. One of the important families of Bt proteins is vegetative insecticidal proteins (Vip), which are secreted into the growth medium during vegetative growth. There are three subfamilies of Vip proteins. Vip1 and Vip2 heterodimer toxins have an insecticidal activity against many Coleopteran and Hemipteran pests. Vip3, the most extensively studied family of Vip toxins, is effective against Lepidopteron. Vip proteins do not share homology in sequence and binding sites with Cry proteins, but share similarities at some points in their mechanism of action. Vip3 proteins are expressed as pyramids alongside Cry proteins in crops like maize and cotton, so as to control resistant pests and delay the evolution of resistance. Biotechnological- and in silico-based analyses are promising for the generation of mutant Vip proteins with an enhanced insecticidal activity and broader spectrum of target insects.

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