Effects of polysaccharide from Pueraria lobata on gut microbiota in mice

文献类型： 外文期刊

第一作者： Chen, Rong

作者： Chen, Rong;Liu, Bo;Wang, Xiaoyang;Chen, Kai;Zhang, Keyu;Zhang, Lifang;Fei, Chenzhong;Wang, Chunmei;Liu, Yingchun;Xue, Feiqun;Gu, Feng;Wang, Mi

作者机构：

关键词： Polysaccharide from Pueraria lobata; Gut microbiota; Short chain fatty acids

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2020 年 158 卷

页码：

收录情况： SCI

摘要： Polysaccharide was derived from Pueraria lobata (PPL) which was considered as one of the traditional Chinese medicinal and edible herbs. In the present study, PPL was administered in equal doses (12.5mg/kg) to both normal mice and antibiotic-associated diarrhea (AAD) mice for two weeks, and was evaluated in terms of body weight, organ indices, gut structure, gut microbiota and short chain fatty acids. The results showed that normal mice treated with PPL not only reduced the isovaleric acid concentration (P < 0.05), but also significantly increased the abundance of beneficial bacteria, involving Oscillospira and Anaerotruncus (P < 0.05). In addition, PPL could relieve colonic pathological changes and gut microbiota dysbiosis caused by AAD. It indicated that PPL was a potential functional food ingredient by modulating gut microbiota. (c) 2020 Elsevier B.V. All rights reserved.

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