Indel variants within thePRLandGHRgenes associated with sheep litter size

文献类型： 外文期刊

第一作者： Akhatayeva, Zhanerke

作者： Akhatayeva, Zhanerke;Pan, Chuanying;Chen, Hong;Lan, Xianyong;Mao, Cui;Lin, Chunjian;Hao, Kunjie;Lan, Tianxin;Zhang, Qingfeng;Mao, Cui;Jiang, Fugui;Lin, Chunjian;Hao, Kunjie;Lan, Tianxin;Zhang, Qingfeng;Jiang, Fugui

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关键词： growth hormone receptor (GHR) gene; indel polymorphisms; litter size; prolactin (PRL) gene; sheep

期刊名称：REPRODUCTION IN DOMESTIC ANIMALS （ 影响因子：2.005； 五年影响因子：2.154 ）

ISSN： 0936-6768

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收录情况： SCI

摘要： Growth hormone and prolactin belong to the class of peptide hormones that have a wide range of regulatory functions. In this study, polymorphisms of growth hormone receptor (GHR) and prolactin (PRL) genes were analysed as candidate genes, which are responsible for the litter size in Australian White (AUW) sheep. According to the statistical analyses results, the polymorphism information content (PIC) values of the PRL-P1-ins-23 bp, GHR-P2-del-23 bp and GHR-P8-del-23 bp were 0.371, 0.366 and 0.375, respectively, which indicates the high genetic polymorphism in AUW sheep. Moreover, all indel loci are not conformed to the HWE (p < .05). Further, our findings revealed that the PRL-P1-ins-23 bp polymorphism in the ovinePRLgene was significantly related to the first parity litter size (p = .001) and the DD genotype displaying the highest genotypic mean. Meanwhile, the GHR-P2-del-23 bp and GHR-P8-23 bp indels in the ovineGHRgene were significantly correlated with first parity litter size (p < .05), and the individuals with the genotype II showed significantly higher litter size than others. Collectively, these results demonstrated that our findings could be useful for future sheep breeding strategies based on the molecular-assisted selection (MAS).

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