Transcriptional identification of differentially expressed genes associated with division of labor inApis cerana cerana

文献类型： 外文期刊

第一作者： Chen, Yi-Jie

作者： Chen, Yi-Jie;Li, Ying-Jiao;Wu, Shuang;Yang, Wen-Chao;Miao, Jing;Li, Jiang-Hong;Miao, Xiao-Qing;Chen, Yi-Jie;Wu, Shuang;Gu, Shao-Hua;Li, Xianchun;Li, Xianchun

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关键词： behavioral transition; epigenetic shift; lncRNA; over-aged nurses; precocious foragers; signaling genes

期刊名称：INSECT SCIENCE （ 影响因子：3.262； 五年影响因子：3.206 ）

ISSN： 1672-9609

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收录情况： SCI

摘要： Workers ofApis cerana ceranaundergo an in-hive nursing to outdoor foraging transition, but the genes underlying this age-related transition remain largely unknown. Here, we sequenced the head transcriptomes of its 7-day-old normal nurses, 18- and 22-day-old normal foragers, 7-day-old precocious foragers and 22-day-old over-aged nurses to unravel the genes associated with this transition. Mapping of the sequence reads toApis melliferagenome showed that the three types of foragers had a greater percentage of reads from annotated exons and intergenic regions, whereas the two types of nurses had a greater percentage of reads from introns. Pair- and group-wise comparisons of the five transcriptomes revealed 59 uniquely expressed genes (18 in nurses and 41 in foragers) and 14 nurse- and 15 forager-upregulated genes. The uniquely expressed genes are usually low-abundance long noncoding RNAs, transcription factors, transcription coactivators, RNA-binding proteins, kinases or phosphatases that are involved in signaling and/or regulation, whereas the nurse- or forager-upregulated genes are often high-abundance downstream genes that directly perform the tasks of nurses or foragers. Taken together, these results suggest that the nurse-forager transition is coordinated by a social signal-triggered epigenetic shift from introns to exons/intergenic regions and the resulting transcriptional shift between the nurse- and forager-associated genes.

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