Current Understanding of the Structure and Function of Fungal Immunomodulatory Proteins

文献类型： 外文期刊

第一作者： Liu, Yusi

作者： Liu, Yusi;Liu, Yusi;Bastiaan-Net, Shanna;Wichers, Harry J.;Liu, Yusi;Wichers, Harry J.

作者机构：

关键词： immunomodulatory proteins; FIPs; glycosylation; immunomodulaion; hemagglutination; structure-function relationship

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.576； ）

ISSN： 2296-861X

年卷期： 2020 年 7 卷

页码：

收录情况： SCI

摘要： Fungal immunomodulatory proteins (FIPs) are a group of proteins found in fungi, which are extensively studied for their immunomodulatory activity. Currently, more than 38 types of FIPs have been described. Based on their conserved structure and protein identity, FIPs can be classified into five subgroups: Fve-type FIPs (Pfam PF09259), Cerato-type FIPs (Pfam PF07249), PCP-like FIPs, TFP-like FIPs, and unclassified FIPs. Among the five subgroups, Fve-type FIPs are the most studied for their hemagglutinating, immunomodulating, and anti-cancer properties. In general, these small proteins consist of 110-125 amino acids, with a molecular weight of similar to 13 kDa. The other four subgroups are relatively less studied, but also show a noticeable influence on immune cells. In this review, we summarized the protein modifications, 3-dimensional structures and bioactivities of all types of FIPs. Moreover, structure-function relationship of FIPs has been discussed, including relationship between carbohydrate binding module and hemagglutination, correlation of oligomerization and cytokine induction, relevance of glycosylation and lymphocyte activation. This summary and discussion may help gain comprehensive understanding of FIPs' working mechanisms and scope future studies.

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