文献类型： 外文期刊
第一作者： Wang, Chunmei
作者： Wang, Chunmei;Liu, Yingchun;Zheng, Haihong;Wang, Xiaoyang;Wang, Mi;Zhang, Lifang;Xue, Feiqun;Zhang, Keyu;Li, Yang;He, Jun
作者机构：
关键词： Autonomic nervous system; Cardiovascular-respiratory system; Central nervous system; Ethanamizuril; Novel triazine coccidiostats
期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）
ISSN： 0034-5288
年卷期： 2020 年 132 卷
页码：
收录情况： SCI
摘要： In the current study, to support the safety pharmacology assessment of Ethanamizuril as a new potent anticoccidial agent of triazine compounds, the effects of Ethanamizuril on the central nervous system, cardiovascular system and respiratory system were investigated. Using locomotor activity test, climbing behavior test and nembutal subthreshold hypnotic test at each time point after oral administration of Ethanamizuril to mice, the effects on the central nervous system were evaluated. An assessment of Ethanamizuril effects on the cardiovascular and respiratory system were performed by the use of a telemetry system in conscious beagle dogs. The results showed that the treatment of Ethanamizuril had no effects on motor activity, behavioral changes, coordination, and sensory/motor reflex responses in mice. There were also no changes in heart rate, blood pressure, and electrocardiogram at all doses and each time points in beagle dogs. Our data suggested that Ethanamizuril showed no adverse effects on the central nervous system, cardiovascular system, and respiratory system.
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