Complex assembly, crystallization and preliminary X-ray crystallographic analysis of duck MHC class I complexed with a TUMV viral peptide
文献类型： 外文期刊
第一作者： Liu, Zixin
作者： Liu, Zixin;Xie, Xiaoli;Li, Zhuolin;Zhang, Nianzhi;Zhang, Lin
作者机构：
关键词： Duck; MHC class I; Peptide; TMUV; Crystallization; Complex assembly
期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）
ISSN： 0034-5288
年卷期： 2020 年 132 卷
页码：
收录情况： SCI
摘要： The CTL immune response mediated by MHC I plays an important role in duck anti-TMUV infection. This study reports the expression, purification and crystallization of a complex of duck MHC class I molecules Anpl-UAA*SD, duck beta 2-microglobulin (Anpl-beta 2m) and the polypeptide LRKRQLTVL (LRK9) derived from Tembusu virus (TMUV) NS3. The crystal diffraction resolution is 1.50 angstrom and belongs to the P6(2) space group, and the unit cell parameters are a = 82.468, b = 82.468, c = 112.507. The Matthew's constant is calculated to be 2.32 angstrom(3) Da(-1), and an asymmetric unit contains a complex molecule with a solvent content of 47%. The research lays the foundation for the structure of immune molecules about duck anti-TMUV research.
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