Ultrastable Near-Infrared Nonlinear Organic Chromophore Nanoparticles with Intramolecular Charge Transfer for Dually Photoinduced Tumor Ablation

文献类型： 外文期刊

第一作者： Zhang, Yi

作者： Zhang, Yi;Wang, Mengya;Xu, Han;Qiu, Shihong;Yang, Hong;Chen, Huabing;He, Hui;Zhang, Yi;Wang, Mengya;Xu, Han;Qiu, Shihong;Yang, Hong;Chen, Huabing;He, Hui;Shi, Mengke;Zhang, Shao;Li, Hongyu;Ying, Yuchen;Chen, Huabing;Guo, Zhengqing;Shi, Mengke;Zhang, Shao;Li, Hongyu;Ying, Yuchen;Chen, Huabing;Guo, Zhengqing;Yan, Zhangren;Liu, Jialei

作者机构：

关键词： near-infrared absorption; organic chromophores; photodynamic therapy; photosensitizers; photothermal therapy

期刊名称：ADVANCED HEALTHCARE MATERIALS （ 影响因子：9.933； 五年影响因子：9.055 ）

ISSN： 2192-2640

年卷期： 2020 年 9 卷 20 期

页码：

收录情况： SCI

摘要： Near-infrared (NIR) light-responsive nanoparticles (NPs) of organic photosensitizers (PS) hold great promise as phototherapeutic agents for precision photoinduced cancer therapy. However, highly photostable PS nanoparticles with extraordinary photoconversion capacities are urgently desired to fully realize potent phototherapy. Here, NIR nonlinear organic chromophore nanoparticles (NOC-NPs) are shown as single-component PS for dually cooperative phototherapy. Upon 785 nm irradiation, excited NOC-NPs pass through intrinsic intramolecular charge transfer (ICT) channel to generate both abundant singlet oxygen and local hyperthermia, affording synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) for tumor ablation. Furthermore, NOC-NPs exhibit dramatic photostability, enhanced cellular uptake, effective cytoplasmic translocation, as well as preferable tumor accumulation, further ensuring favorable in vivo singlet oxygen generation and hyperthermia for photoinduced tumor ablation. Thus, NOC-NPs may represent novel high-performance PS for synergistic photoinduced cancer therapy, providing new insights into the development of potent PS for clinical translation.

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