Air pollution could drive global dissemination of antibiotic resistance genes

文献类型： 外文期刊

第一作者： Zhu, Guibing

作者： Zhu, Guibing;Wang, Xiaomin;Qin, Yu;Wang, Shanyun;Lan, Bangrui;Liu, Chunlei;Zhu, Yong-Guan;Yang, Ting;Wang, Zifa;Su, Jianqiang;Li, Hu;Zhu, Yong-Guan;Gillings, Michael;Wang, Cheng;Ju, Feng;Long, Xi-En;Wang, Xuming;Jetten, Mike S. M.

作者机构：

期刊名称：ISME JOURNAL （ 影响因子：10.302； 五年影响因子：12.284 ）

ISSN： 1751-7362

年卷期：

页码：

收录情况： SCI

摘要： Antibiotic-resistant pathogens pose a significant threat to human health. Several dispersal mechanisms have been described, but transport of both microbes and antibiotic resistance genes (ARGs) via atmospheric particles has received little attention as a pathway for global dissemination. These atmospheric particles can return to the Earth's surface via rain or snowfall, and thus promote long-distance spread of ARGs. However, the diversity and abundance of ARGs in fresh snow has not been studied and their potential correlation with particulate air pollution is not well explored. Here, we characterized ARGs in 44 samples of fresh snow from major cities in China, three in North America, and one in Europe, spanning a gradient from pristine to heavily anthropogenically influenced ecosystems. High-throughput qPCR analysis of ARGs and mobile genetic elements (MGEs) provided strong indications that dissemination of ARGs in fresh snow could be exacerbated by air pollution, severely increasing the health risks of both air pollution and ARGs. We showed that snowfall did effectively spread ARGs from point sources over the Earth surface. Together our findings urge for better pollution control to reduce the risk of global dissemination of antibiotic resistance genes.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序