Cytotoxic xanthones from the plant endophytic fungusPaecilamycessp. TE-540

文献类型： 外文期刊

第一作者： Li, Xiu-Qi

作者： Li, Xiu-Qi;Xu, Kuo;Yuan, Xiao-Long;Liu, Xin-Min;Zhang, Peng;Li, Xiu-Qi;Dong, Quan-Jiang

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关键词： endophytic fungus; Paecilamycessp; secondary metabolites; xanthones; cytotoxicity

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

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收录情况： SCI

摘要： One new xanthone, chryxanthone C (1), together with four known analogues (2-5), were isolated from the cultures ofPaecilamycessp. TE-540, an endophytic fungus obtained from the leaves ofNicotiana tabacumL. The structure of1was elucidated by comprehensive spectral analysis including HRESIMS and 1D/2D NMR, which were confirmed by Cu K alpha X-ray crystallography. Compound1featured an unusual dihydropyran ring fused to an aromatic ring, rather than the commonly occurring prenyl moiety. The cytotoxicity of compounds1-5were evaluated against five human tumour cell lines and4exhibited moderate to strong cytotoxicities with IC(50)values ranging from 5.6 to 14.2 mu M.

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