Genome of Tetraploid Fish Schizothorax o'connori Provides Insights into Early Re-diploidization and High-Altitude Adaptation

文献类型： 外文期刊

第一作者： Xiao, Shijun

作者： Xiao, Shijun;Mou, Zhenbo;Zhou, Chaowei;Liu, Yanchao;Liu, Fei;Wang, Wanliang;Zeng, Benhe;Liu, Haiping;Xiao, Shijun;Zou, Ming;Zou, Yu;Liu, Jiaqi;Zhu, Shilin;Fan, Dingding;Yang, Ruibin;Zhou, He;Li, Yajuan;Zhou, Chaowei;Xiao, Shijun;Li, Hong;Wang, Di

作者机构：

期刊名称：ISCIENCE （ 影响因子：5.458； 五年影响因子：5.458 ）

ISSN：

年卷期： 2020 年 23 卷 9 期

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收录情况： SCI

摘要： Whole-genome duplications (WGDs) of Schizothoracinae are believed to have played a significant role in speciation and environmental adaptation on the Qinghai-Tibet Plateau (QTP). Here, we present a genome for Schizothorax o'connori, a QTP endemic fish and showed the species as a young tetraploid with a recent WGD later than similar to 1.23 mya. We exhibited that massive insertions between duplicated genomes caused by transposon bursts could induce mutagenesis in adjacent sequences and alter the expression of neighboring genes, representing an early re-diploidization process in a polyploid genome after WGD. Meanwhile, we found that many genes involved in DNA repair and folate transport/metabolism experienced natural selection and might contribute to the environmental adaptation of this species. Therefore, the S. o'connori genome could serve as a young tetraploid model for investigations of early re-diploidization in polyploid genomes and offers an invaluable genetic resource for environmental adaptation studies of the endemic fish of the QTP.

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