Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

文献类型： 外文期刊

第一作者： Yang, Jing

作者： Yang, Jing;Huang, Xinmei;Liu, Yuzhuo;Zhao, Dongmin;Han, Kaikai;Zhang, Lijiao;Li, Yin;Liu, Qingtao;Huang, Xinmei;Zhao, Dongmin;Han, Kaikai;Li, Yin

作者机构：

关键词： microRNA; chicken dendritic cell; pathogenesis; host defense response

期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）

ISSN： 0928-4249

年卷期： 2020 年 51 卷 1 期

页码：

收录情况： SCI

摘要： MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.

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