MiR-92b-3p inhibits proliferation and migration of C2C12 cells

文献类型： 外文期刊

第一作者： Ye, Zijian

作者： Ye, Zijian;Shi, Jia;Ning, Zuocheng;Hou, Lianjie;Wang, Chong;Hu, Ching Yuan

作者机构：

关键词： miR-92b-3p; SGK3; proliferation; migration

期刊名称：CELL CYCLE （ 影响因子：4.534； 五年影响因子：4.492 ）

ISSN： 1538-4101

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收录情况： SCI

摘要： Skeletal muscle, a critical component of the mammalian body, is essential for normal body movement. miRNAs are well documented in gene post-transcription regulation in many biological processes, including muscle development and maintenance. miR-92b-3p, which is often associated with tumorigenesis, has never been explored in myoblast development. Here, we used murine-derived C2C12 myoblasts to explore the potential functions of miR-92b-3p in skeletal muscle development. Our results demonstrated that miR-92b-3p mimics inhibited C2C12 cell proliferation and migration, whereas miR-92b-3p inhibitor promoted C2C12 cell proliferation and migration. C2C12 cell differentiation was not affected by miR-92b-3p mimics, according to immunofluorescence and qPCR results. Serum- and glucocorticoid-induced kinase 3 (SGK3) was predicted and validated as a target of miR-92b-3p. Overexpression of SGK3 promoted C2C12 cell proliferation. SGK3 and miR-92b-3p formed a regulatory pathway to modulate C2C12 cell proliferation. In conclusion, miR-92b-3p inhibited C2C12 cell proliferation by targeting SGK3 and impeded C2C12 cell migration.

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