Advances in the Development of Anti-Haemonchus contortus Vaccines: Challenges, Opportunities, and Perspectives

文献类型： 外文期刊

第一作者： Ehsan, Muhammad

作者： Ehsan, Muhammad;Hu, Rui-Si;Liang, Qin-Li;Hou, Jun-Ling;Zhu, Xing-Quan;Song, Xiaokai;Yan, Ruofeng;Li, Xiangrui;Zhu, Xing-Quan

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关键词： Haemonchus contortus; immune responses; host-parasite interactions; vaccine

期刊名称：VACCINES （ 影响因子：4.422； 五年影响因子：5.513 ）

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年卷期： 2020 年 8 卷 3 期

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收录情况： SCI

摘要： The gastrointestinal nematode parasite Haemonchus contortus(H. contortus) is a resident of tropical and subtropical regions worldwide that imposes significant production losses, economic losses, and animal health issues in the small ruminant industry, particularly sheep and goats. Considerable efforts have been made to understand how immunity is elicited againstH. contortusinfection. Various potential vaccine antigens have been tested by different methods and strategies applied in animal models, and significant progress has been made in the development of vaccines agains tH. contortus. This review highlighted and shared the knowledge about the current understanding of host immune responses toH. contortusand ongoing challenges in the development of a protective, effective, and long-lasting vaccine against H. contortus infection. We have also pinpointed some achievements and failures in the development and testing of vaccines, which will establish a road map for future research directions to explore new effective vaccine candidates for controlling and preventing H. contortus infection.

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