Ascorbic Acid Derivative 2-O-beta-D-Glucopyranosyl-L-Ascorbic Acid from the Fruit of Lycium barbarum Modulates Microbiota in the Small Intestine and Colon and Exerts an Immunomodulatory Effect on Cyclophosphamide-Treated BALB/c Mice

文献类型： 外文期刊

第一作者： Huang, Kaiyin

作者： Huang, Kaiyin;Chen, Dan;Zhao, Ya;Dong, Wei;Zeng, Xiaoxiong;Yan, Yamei;Cao, Youlong;Yan, Yamei;Cao, Youlong

作者机构：

关键词： Lycium barbarum; 2-O-beta-D-glucopyranosyl-L-ascorbic acid; immunomodulatory effect; microbiota; small intestine; colon; Muribaculaceae

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2020 年 68 卷 40 期

页码：

收录情况： SCI

摘要： 2-O-beta-D-Glucopyranosyl-L-ascorbic acid (AA-2 beta G) is a natural and stable ascorbic acid derivative isolated from the fruits of Lycium barbarum. In our present study, cyclophosphamide (Cy) was used to make BALB/c mice immunosuppressive and AA-2 beta G was used to intervene immunosuppressive mice. It was found that Cy treatment resulted in a series of changes on basic immune indexes including a decrease of thymus and spleen indexes and levels of pro-inflammatory cytokines and destruction of leucocyte proportion balance, accompanied with weight loss, reduction in colon length, and changes of hepatic function markers. However, all these changes were reversed in varying degrees by AA-2 beta G intervention. Notably, AA-2 beta G could significantly change both mouse colonic and small-intestinal microbiota. The key responsive taxa found in a mouse colon were Muribaculaceae, Ruminococcaceae, Oscillibacter, Rikenella, Helicobacter, Negativibacillus, Alistipes, and Roseburia, and the key responsive taxa found in a mouse small intestine were Muribaculaceae, Anaerotruncus, and Paenibacillus. The results demonstrated that AA-2 beta G could modulate microbiota in the small intestine and colon and exert an immunomodulatory effect. Further studies should focus on the degradation pathways of AA-2 beta G and the interaction between AA-2 beta G and Muribaculaceae.

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