Herbicidal and Antifungal Xanthone Derivatives from the Alga-Derived Fungus Aspergillus versicolor D5

文献类型： 外文期刊

第一作者： Zhao, Dong-Lin

作者： Zhao, Dong-Lin;Wang, Mei;Li, Yi-Qiang;Zhang, Peng;Zhang, Cheng-Sheng;Han, Xiao-Bin;Zeng, Yun-Tao;Ma, Guo-Yong;Liu, Jing;Wen, Ming-Xia;Zhang, Zhi-Fan;Zheng, Cai-Juan

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关键词： xanthone; herbicidal; antifungal; Aspergillus versicolor; biopesticide

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2020 年 68 卷 40 期

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收录情况： SCI

摘要： Fungi have been proved as promising and prolific sources of functional secondary metabolites with potent agricultural applications. In this study, 14 xanthone derivatives (1-14), including six new ones, versicones I-N (1-4, 7, 11), and a biogenetically related derivative (15), were isolated from the alga-derived fungus Aspergillus versicolor D5. Their structures were elucidated by comprehensive spectroscopic methods. Versicone L ( 4) exhibited a broad antifungal spectrum and prominent inhibitory effects on Botrytis cinerea at a minimum inhibitory concentration (MIC) of 152 mu M, 7-fold stronger than that of the positive control, carbendazim (MIC = 1.05 x 10(3) mu M). Dihydrosterigmatocystin (13) showed strong antifungal activity toward B. cinerea at MIC = 38.3 mu M, almost 30-fold stronger than that of carbendazim. Meanwhile, 13 exhibited potent herbicidal activity toward Amaranthus retroflexus L. with an MIC of 24.5 mu M, approximately 4-fold stronger than that of the positive control, glyphosate (MIC = 94.7 mu M). Additionally, 13 also displayed remarkable activity against other weeds belonging to Amaranth sp. Analysis of the structure-herbicidal activity relationship indicated that the bifuranic ring played an important role in xanthone phytotoxicity and the presence of a double bond in the furan ring could decrease phytotoxicity. This study indicated that xanthones can be served as promising candidates for lead compounds of agrochemicals.

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