文献类型： 外文期刊
第一作者： Dong, Zhaomin
作者： Dong, Zhaomin;Fan, Xiarui;Fan, Wenhong;Xu, Yilu;Dong, Zhaomin;Fan, Wenhong;Chang, Hong;Xu, Yilu;Li, Tong;Su, Ming
作者机构：
关键词： Pharmacokinetic; Pkweb; R shiny; Online application; Prior parameters
期刊名称：ENVIRONMENTAL TECHNOLOGY & INNOVATION （ 影响因子：5.263； 五年影响因子：5.116 ）
ISSN： 2352-1864
年卷期： 2020 年 19 卷
页码：
收录情况： SCI
摘要： This research presents a web-based application, pkweb (https://pkweb.hhra.net), with a user-friendly interface and a range of functions for pharmacokinetic (PK) data analysis. Capabilities include simulation of PK data, which integrates 27 modules (e.g., intravenous (IV) bolus injection, IV infusion and extravascular administration) and modeling the fitness of PK data. The pkweb tool provides different solutions for various conditions, such as compartmental analysis (CA) under single dosing, non-compartmental analysis (NCA) under single dosing and CA under multiple dosing. Compared to other tools, a unique feature of this tool is the ability to set boundaries for the parameters of each model. This newly released application promises to facilitate both toxicokinetic and pharmacokinetic data analysis. (C) 2020 Elsevier B.V. All rights reserved.
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