The Compromised Intestinal Barrier Induced by Mycotoxins

文献类型： 外文期刊

第一作者： Gao, Yanan

作者： Gao, Yanan;Meng, Lu;Liu, Huimin;Wang, Jiaqi;Zheng, Nan;Gao, Yanan;Meng, Lu;Liu, Huimin;Wang, Jiaqi;Zheng, Nan;Gao, Yanan;Meng, Lu;Liu, Huimin;Wang, Jiaqi;Zheng, Nan;Gao, Yanan;Meng, Lu;Liu, Huimin;Wang, Jiaqi;Zheng, Nan

作者机构：

关键词： mycotoxins; intestinal barrier; intestinal inflammation; interactive effects

期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）

ISSN：

年卷期： 2020 年 12 卷 10 期

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收录情况： SCI

摘要： Mycotoxins are fungal metabolites that occur in human foods and animal feeds, potentially threatening human and animal health. The intestine is considered as the first barrier against these external contaminants, and it consists of interconnected physical, chemical, immunological, and microbial barriers. In this context, based on in vitro, ex vivo, and in vivo models, we summarize the literature for compromised intestinal barrier issues caused by various mycotoxins, and we reviewed events related to disrupted intestinal integrity (physical barrier), thinned mucus layer (chemical barrier), imbalanced inflammatory factors (immunological barrier), and dysfunctional bacterial homeostasis (microbial barrier). We also provide important information on deoxynivalenol, a leading mycotoxin implicated in intestinal dysfunction, and other adverse intestinal effects induced by other mycotoxins, including aflatoxins and ochratoxin A. In addition, intestinal perturbations caused by mycotoxins may also contribute to the development of mycotoxicosis, including human chronic intestinal inflammatory diseases. Therefore, we provide a clear understanding of compromised intestinal barrier induced by mycotoxins, with a view to potentially develop innovative strategies to prevent and treat mycotoxicosis. In addition, because of increased combinatorial interactions between mycotoxins, we explore the interactive effects of multiple mycotoxins in this review.

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