In Vitro Digestion and Fermentation by Human Fecal Microbiota of Polysaccharides from Flaxseed

文献类型： 外文期刊

第一作者： Zhou, Xin

作者： Zhou, Xin;Zhang, Zhao;Huang, Fenghong;Yang, Chen;Huang, Qingde

作者机构：

关键词： flaxseed polysaccharides; simulated digestion; gut microbiota; in vitro fermentation

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

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年卷期： 2020 年 25 卷 19 期

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收录情况： SCI

摘要： The digestion of flaxseed polysaccharides (FSP) in simulated saliva, gastric and small intestine conditions was assessed, as well as in vitro fermentation of FSP by human gut microbiota. FSP was not degraded in the simulated digestive systems (there was no change in molecular weight or content of reducing sugars), indicating that ingested FSP would reach the large intestine intact. Changes in carbohydrate content, reducing sugars and culture pH suggested that FSP could be broken down and used by gut microbiota. FSP modulated the composition and structure of the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundances of Prevotella, Phascolarctobacterium, Clostridium and Megamonas, which can degrade polysaccharides. Meanwhile, FSP fermentation increased the concentration of short-chain fatty acids, especially propionic and butyric acids. Our results indicate that FSP might be developed as a functional food that benefits gut health.

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