Genome editing for plant synthetic metabolic engineering and developmental regulation

文献类型： 外文期刊

第一作者： Tan, Jiantao

作者： Tan, Jiantao;Shen, Mengyuan;Liu, Qi;Chai, Nan;Liu, Yao-Guang;Zhu, Qinlong

作者机构：

关键词： Genome editing; Synthetic metabolic engineering; Developmental regulation; Plant breeding

期刊名称：JOURNAL OF PLANT PHYSIOLOGY （ 影响因子：4.3； 五年影响因子：4.5 ）

ISSN： 0176-1617

年卷期： 2023 年 291 卷

页码：

收录情况： SCI

摘要： Plant metabolism and development are a reflection of the orderly expression of genetic information intertwined with the environment interactions. Genome editing is the cornerstone for scientists to modify endogenous genes or introduce exogenous functional genes and metabolic pathways, holding immense potential applications in molecular breeding and biosynthesis. Over the course of nearly a decade of development, genome editing has advanced significantly beyond the simple cutting of double-stranded DNA, now enabling precise base and fragment replacements, regulation of gene expression and translation, as well as epigenetic modifications. However, the utilization of genome editing in plant synthetic metabolic engineering and developmental regulation remains exploratory. Here, we provide an introduction and a comprehensive overview of the editing attributes associated with various CRISPR/Cas tools, along with diverse strategies for the meticulous control of plant metabolic pathways and developments. Furthermore, we discuss the limitations of current approaches and future prospects for genome editing-driven plant breeding.

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