文献类型： 外文期刊

第一作者： Aldamarany, Waleed A. S.

作者： Aldamarany, Waleed A. S.;Yi, Zhao;Zhong, Geng;Aldamarany, Waleed A. S.;Taocui, Huang;Mei, Han;Deng, Liling;Zhong, Geng

作者机构：

关键词： Perilla oil; Sunflower oil; Tea seed oil; Anti-obesity; Inflammation; Gut microbiota

期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：4.1； 五年影响因子：4.6 ）

ISSN： 1436-6207

年卷期： 2023 年 62 卷 6 期

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收录情况： SCI

摘要： PurposeObesity has become a serious public health problem with its alarmingly increasing prevalence worldwide, prompting researchers to create and develop several anti-obesity drugs. Here, we aimed to investigate the protective effects of perilla seed oil (PSO), sunflower oil (SFO), and tea seed oil (TSO) against obesity through the modulation of the gut microbiota composition and related metabolic changes in mice fed a high-fat diet (HFD).MethodsMice were divided into six equal groups: ND (normal diet); HFD; ORL (HFD supplemented with 20 mg/kg body weight of orlistat); PSO, SFO, and TSO (HFD supplemented with 2 g/kg body weight of PSO, SFO, and TSO, respectively).ResultsOur findings showed that PSO, SFO, and TSO supplementation significantly reduced body weight, organ weight, blood glucose, lipopolysaccharides (LPS), insulin resistance, and improved serum lipid levels (TG, TC, LDL-C, and HDL-C). Meanwhile, the three treatments alleviated oxidative stress and hepatic steatosis and reduced liver lipid accumulation. Relative mRNA expression levels of inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6, and MCP-1) and lipid synthesis-related genes (PPAR-gamma, FAS, and SREBP-1) were down-regulated, while beta-oxidation-related genes (PPAR-alpha, CPT1a, and CPT1b) were up-regulated in the liver tissue of treated mice. Besides, dietary oil supplementation alleviated HFD-induced gut microbiota dysbiosis by promoting gut microbiota richness and diversity, decreasing the Firmicutes-to-Bacteroidetes ratio, and boosting the abundance of some healthy bacteria, like Akkermansia.ConclusionsPSO, SFO, and TSO supplementation could alleviate inflammation, oxidative stress, and hepatic steatosis, likely by modulating the gut microbiota composition in HFD-fed mice.

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