Retrotransposon-mediated evolutionary rewiring of a pathogen response orchestrates a resistance phenotype in an insect host

文献类型： 外文期刊

第一作者： Guo, Zhaojiang

作者： Guo, Zhaojiang;Guo, Le;Bai, Yang;Kang, Shi;Sun, Dan;Qin, Jianying;Ye, Fan;Wang, Shaoli;Wu, Qingjun;Xie, Wen;Yang, Xin;Zhang, Youjun;Crickmore, Neil;Zhou, Xuguo

作者机构：

关键词： Plutellaxylostella; Bacillus thuringiensis; genetic variation; retrotransposon; FOXO transcription factor

期刊名称：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA （ 影响因子：11.1； 五年影响因子：12.0 ）

ISSN： 0027-8424

年卷期： 2023 年 120 卷 14 期

页码：

收录情况： SCI

摘要： Ongoing host-pathogen interactions can trigger a coevolutionary arms race, while genetic diversity within the host can facilitate its adaptation to pathogens. Here, we used the diamondback moth (Plutella xylostella) and its pathogen Bacillus thuring-iensis (Bt) as a model for exploring an adaptive evolutionary mechanism. We found that insect host adaptation to the primary Bt virulence factors was tightly associated with a short interspersed nuclear element (SINE -named SE2) insertion into the pro-moter of the transcriptionally activated MAP4K4 gene. This retrotransposon insertion coopts and potentiates the effect of the transcription factor forkhead box O (FOXO) in inducing a hormone-modulated Mitogen-activated protein kinase (MAPK) sign-aling cascade, leading to an enhancement of a host defense mechanism against the pathogen. This work demonstrates that reconstructing a cis-trans interaction can escalate a host response mechanism into a more stringent resistance phenotype to resist pathogen infection, providing a new insight into the coevolutionary mechanism of host organisms and their microbial pathogens.

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