Characteristics of casein phosphopeptides in Chinese human milk and its correlation with infant growth: A cross-sectional study

文献类型： 外文期刊

第一作者： Han, Muke

作者： Han, Muke;Xu, Yajun;Han, Muke;Xu, Yajun;Li, Kaifeng;Sun, Han;Xie, Qinggang;Jiang, Shilong;Fang, Yuehui;Fang, Yuehui;Chen, Baorong;Zhang, Shuwen;Lv, Jiaping

作者机构：

关键词： Casein phosphopeptides; Human milk; Infant growth; Mass spectrometry; Z-scores

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 447 卷

页码：

收录情况： SCI

摘要： This research aimed to investigate the characteristics of casein phosphopeptides in Chinese human milk, and their potential relationship to infant growth. Using the liquid chromatography-Orbitrap-mass spectrometry technique, a total of 15 casein phosphopeptides were identified from 200 human milk samples. Also, our results indicate that casein phosphopeptides were phosphorylated with only one phosphate. The relative concentrations of casein phosphopeptides at 6 months postpartum were increased compared with milk at 2 months (FDR < 0.05). Significantly positive correlations were observed between casein phosphopeptides and infant growth, as shown by four casein phosphopeptides were positively correlated with the infants' weight-for-age Z-scores (r(s) range from 0.20 to 0.29), and three casein phosphopeptides were positively correlated with the infants' length-for-age Z-scores (r(s) range from 0.19 to 0.27). This study is the first to reveal the phosphorylated level and composition of casein phosphopeptides in Chinese human milk, and their potential relationship with infant growth.

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