Revisiting IRF1-mediated antiviral innate immunity

文献类型： 外文期刊

第一作者： Tang, Yan-Dong

作者： Tang, Yan-Dong;Zheng, Chunfu;Zhou, Hao;Tang, Yan-Dong;Zheng, Chunfu

作者机构：

关键词： IRF1; IFN dependent and independent loop; Positive feedback; Antiviral immunity

期刊名称：CYTOKINE & GROWTH FACTOR REVIEWS （ 影响因子：17.66； 五年影响因子：12.32 ）

ISSN： 1359-6101

年卷期： 2022 年 64 卷

页码：

收录情况： SCI

摘要： Many studies have been conducted over the last few decades to understand better the functions of IRF3 and IRF7 in antiviral immune responses. However, the precise underlying molecular mechanism of IRF1-mediated immune response remains largely unknown. Recent studies indicate that IRF1 exerts strong antiviral activities against several viral infections through diverse mechanisms, both in IFN-dependent and IFN-independent manners. Nevertheless, the efficacy and kinetics of inducing IFNs and ISGs remain unknown. Here we summarize the recent advances in IRF1 research and highlight its potential roles in initiating IFN immune responses and subsequent IRF1-triggering antiviral responses. Challenges regarding the IFN positive feedback mediated by IRF7 during infection will be discussed; this classical loop may also be mediated in part by IRF1. Therefore, we propose a revised model that may help decipher the functional roles of IRF1 in antiviral immunity.

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